Neurology: Neurochemistry, Neuropharmacology and Neurosciences

Statement of the Problem: GBM is the most common intra-axial primary brain tumor. It is a highly malignant, rapidly progressive astrocytoma which is characterized by its wide range of clinical, pathological and morphological appearance. (In US) Over 13,000 deaths are attributed to gliomas annually and approximately 18,000 new cases are diagnosed each year. Increasing age correlates to incidence. Although there are many treatments available for GBM including surgical resection, chemotherapy and radiation, prognosis remains bleak. The average survival time is only 14 months. Furthermore, the five-year survival rate of GBM is also only 10%. Assessing possible risk factors remains a major focus of disease prevention. Method: The patients histologically confirmed as glioblastoma were included in the study,  clinical approaches together with lab and radiological investigation was done, then surgery planning done and complications predicted and survival were collected and statistically collected and classified using (SPSS) system to demonstrate the statistically significant variables . My study main objectives were comparative of clinical features and demographical prevalence in Iraqi patients, mobile usage effect on developing of glioblastoma multiforme and finally we predict the patients outcome after surgical management. Findings: Most of patients died after 9 months of diagnosis and few others cases died during final preparation of this study, the age, geographical area, history of mobile usage, KPS, radiotherapy, type and the extent of the surgery were main prognostic factors affecting the survival rate. Conclusion & Recommendations: The overall survival rate of the patients was very short (not exceeding 9 months). Age, KPS, type and the extent of the surgery, radiotherapy all affect the survival rate. Early surgical intervention to avoid further neurological deterioration, complete surgical resection whenever possible, improving and updating neurosurgical operative techniques, reduction in mobile usage duration, improve the standardization and quality control for mobile phone which not meet the international standards (like FCC), further future study for Iraqi area with high incidence rate.